![]() ![]() ![]() In vitro work with DCA on neuroblastomas (which have fewer recognised mitochondrial abnormalities) showed activity against malignant, undifferentiated cells. Observations in vitro and of tumours extracted from those five patients suggest that DCA might act against cancer cells by depolarising abnormal mitochondria found in glioblastoma cancer cells – allowing the mitochondria to induce apoptosis (cell death) of the malignant cells. All five patients were receiving other treatments during the study. This study was rather to see whether it could be given at a specific dosage safely without causing side effects (e.g. The only monitored in vivo dosage of five human patients suffering from glioblastoma with DCA was not designed to test its efficacy against their cancer. ![]()
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